文献摘要：R.Huhn,A.Heinen，Hyperglycaemiablockssevoflurane-inducedpostconditioningintheratheartinvivo:cardioprotectioncanberestoredbyblockingthemitochondrialpermeabilitytransitionpore，BritishJournalofAnaesthesia(4):–71().

Abstract:

Background.Recentstudiesshowedthathyperglycaemia(HG)blocksanaesthetic-inducedpreconditioning.TheinfluenceofHGonanaesthetic-inducedpostconditioning(post)hasnotyetbeendetermined.Weinvestigatedwhethersevoflurane(Sevo)-inducedpostconditioningisblockedbyHGandwhethertheblockadecouldbereversedbyinhibitingthemitochondrialpermeabilitytransitionpore(mPTP)withcyclosporineA(CsA).

Methods.Chloralose-anaesthetizedrats(n?7–11pergroup)weresubjectedto25mincoronaryarteryocclusionfollowedbyminreperfusion.Postconditioningwasachievedbyadministrationof1or2MACsevofluraneforthefirst5minofearlyreperfusion.HGwasinducedbyinfusionofglucose50%(G50)for35min,starting5minbeforeischaemiaupto5minofreperfusion.CsA(5or10mgkg21)wasadministeredi.v.5minbeforetheonsetofreperfusion.Attheendoftheexperiments,heartswereexcisedforinfarctsize

measurements.

Results.Infarctsize(%ofareaatrisk)wasreducedfrom51.4(5.0)%[mean(SD)]incontrolsto32.7(12.8)%aftersevofluranepostconditioning(Sevo-post)(P0.05).Thisinfarctsizereductionwas







































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