LvY1,LiuB2,WangHP3,ZhangL1.IntramyocardialimplantationofdifferentiatedratbonemarrowmesenchymalstemcellsenhancedbyTGF-β1improvescardiacfunctioninheartfailurerats.BrazJMedBiolRes.;49(6):e.doi:10./-X.EpubMay31.

Thepresentstudytestedthehypothesesthati)transforminggrowthfactorbeta1(TGF-β1)enhancesdifferentiationofratbonemarrowmesenchymalstemcells(MSCs)towardsthecardiomyogenicphenotypeandii)intramyocardialimplantationoftheTGF-β1-treatedMSCsimprovescardiacfunctioninheartfailurerats.MSCsweretreatedwithdifferentconcentrationsofTGF-β1for72h,andthenmorphologicalcharacteristics,surfaceantigensandmRNAexpressionofseveraltranscriptionfactorswereassessed.IntramyocardialimplantationoftheseTGF-β1-treatedMSCstoinfarctedheartwasalsoinvestigated.MSCswereinitiallyspindle-shapedwithirregularprocesses.Onday28afterTGF-β1treatment,MSCsshowedfusiformshape,orientatingparallelwithoneanother,andwereconnectedwithadjoiningcellsformingmyotube-likestructures.Immunofluorescencerevealedtheexpressionofcardiomyocyte-specificproteins,α-sar







































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