SGLT2inhibitionwithempagliflozinattenuatesmyocardialoxidativestressandfibrosisindiabeticmiceheartCardiovascDiabetolOriginalinvestigationDec01,:18(1),./s---2本文由“天纳”临床学术信息人工智能系统自动翻译BackgroundHyperglycaemiaassociatedwithmyocardialoxidativestressandfibrosisisthemaincauseofdiabeticcardiomyopathy.Empagliflozin,asodium-glucosecotransporter2(SGLT2)inhibitorhasrecentlybeenreportedtoimproveglycaemiccontrolinpatientswithtype2diabetesinaninsulin-independentmanner.Theaimofthisstudywastoinvestigatetheeffectofempagliflozinonmyocardiuminjuryandthepotentialmechanismintype2diabeticKK-Aymice.与心肌氧化应激和纤维化相关的高血糖是糖尿病性心肌病的主要原因。Empagliflozin是一种钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂，最近被报道以胰岛素独立的方式改善2型糖尿病患者的血糖控制。本研究的目的是探讨empaglifozin对2型糖尿病kk-ay小鼠心肌损伤的影响及其可能的机制。MethodsThirtydiabeticKK-Aymicewereadministeredempagliflozin(10?mg/kg/day)byoralgavagedailyfor8?weeks.After8?weeks,heartstructureandfunctionwereevaluatedbyechocardiography.Oxidantsandantioxidantsweremeasuredandcardiacfibrosiswasanalysedusingimmunohistochemistry,Masson’strichromestainandWesternblot.30只糖尿病KK-AY小鼠每日经口灌胃给予Empagliflozin（10mg/kg/天），持续8周。8周后，通过超声心动图评估心脏结构和功能。用免疫组化、Masson三色染色和Westernblot检测氧化剂和抗氧化剂，分析心肌纤维化。ResultsResultsshowedthatempagliflozinimproveddiabeticmyocardialstructureandfunction,decreasedmyocardialoxidativestressandamelioratedmyocardialfibrosis.Furtherstudyindicatedthatempagliflozinsuppressedoxidativestressandfibrosisthroughinhibitionofthetransforminggrowthfactorβ/SmadpathwayandactivationofNrf2/AREsignaling.结果表明，empaglifozin可改善糖尿病患者的心肌结构和功能，降低心肌氧化应激，改善心肌纤维化。进一步的研究表明，Empagliflozin通过抑制转化生长因子β/Smad途径和激活nrf2/ARE信号来抑制氧化应激和纤维化。ConclusionsGlycaemiccontrolwithempagliflozinsignificantlyamelioratedmyocardialoxidativestressinjuryandcardiacfibrosisindiabeticmice.Takentogether,theseresultsindicatethattheempagliflozinisapromisingagentforthepreventionandtreatmentofdiabeticcardiomyopathy.用empaglifozin控制血糖可显著改善糖尿病小鼠的心肌氧化应激损伤和心肌纤维化。综上所述，这些结果表明，empaglifozin是一种很有希望的药物，预防和治疗糖尿病心肌病。IntroductionTheglobalincidenceofdiabetesmellitus(DM)hasgraduallyincreasedoverthepastthreedecadesandhasbe







































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